Knoxville/Maryville to Murphysboro (TYS–MDH) — Airlines, Schedules & Connections

TYS Airport Page →
321 mi airlines 0/wk
On-time Some delays Frequent delays
Connecting Flight Schedule 2 1-stop flights Verified 1mo ago
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  Flight Airline AC Dep Arr Dur OTP Sched  
✈ Nonstop

No flights match your filters.

No nonstop flights on this route. connecting options below.

✦ 1-STOP More options, longer trips
✧ 2-STOP Loading... Reach the hardest destinations
Knoxville/Maryville to Murphysboro
Connecting service available through multiple hubs.
321 mi 1h 33m nonstop -1h behind 2 1-stop hubs

While no nonstop service exists between TYS and MDH, connecting options are available through 2 hubs.

Also explore TYS Routes MDH Routes TYS Live Flights MDH Live Flights TYS Delays
Connections

Connection Landscape

Beyond nonstop. 1-stop and 2-stop options for TYS to MDH.
1-STOP
One-Stop Connections
2
Hubs
~3h
Fastest
~6h
Longest
Verified with published schedule alignment and minimum connection time.
Connections computed from published schedules with minimum connection time verification. Use the interactive explorer above the fold to filter by airline, tier, and layover time.
Alternatives

Other ways to reach Murphysboro from Knoxville/Maryville

Nearby airports with service to Southern Illinois Airport.
Metric TYS→MDH LEX→MDH
Distance from TYS – 157 mi
Nonstop airlines 0 1
Weekly flights 0 –
Flight time 1h 33m 1h 11m
Departure OTP 77% –
Lexington (LEX) to Murphysboro flights
Airports within 200 miles of TYS with service to Southern Illinois Airport.
Know before you go

Travel Essentials

Practical planning for this route.
Time Difference
-1h
Murphysboro is 1 hour behind Knoxville/Maryville.
TYS: EDT · MDH: CDT

When it's 6:00 PM in Knoxville/Maryville, it's 5:00 PM in Murphysboro.
Distance & Flight Time
321 mi / 517 km
Nonstop flight time is approximately 1h 33m.
Facts

TYS–MDH Quick Facts

Key statistics for the Knoxville/Maryville to Murphysboro route.
Route details
Distance321 mi / 517 km
Flight time1h 33m
Time difference-1 hour
Airlines (nonstop)0
1-stop connections2 hubs
Origin: TYS
Full nameMcGhee Tyson Airport
IATA / ICAOTYS / KTYS
TimezoneAmerica/New_York
Passengers/yr3.3M
Elevation981 ft / 299 m
Destination: MDH
Full nameSouthern Illinois Airport
IATA / ICAOMDH / KMDH
TimezoneAmerica/Chicago
Elevation411 ft / 125 m
FAQ

Frequently Asked Questions

Common questions about TYS to MDH flights.
Nonstop flights from McGhee Tyson Airport to Southern Illinois Airport take approximately 1h 33m. The route covers 321 miles.
Yes, 1-stop connections are available through MDW and MIA. These options provide additional schedule flexibility.
Murphysboro is 1 hour behind Knoxville/Maryville.
Nearby alternatives include LEX. See the Alternatives section for a full comparison.
Click the 'Search Flights' button to check availability and prices on Google Flights. You can also compare airlines and schedules on this page to find the best option.
See the On-Time Performance section for the latest delay data at both airports. This shows departure and arrival reliability to help you plan.
Route data is updated regularly from official airline schedules. On-time performance data comes from recent airport delay snapshots.

Flights from TYS to MDH

McGhee Tyson Airport (TYS) and Southern Illinois Airport (MDH) are connected through multiple connecting hub airports.

TYS to MDH Flight Duration and Schedule

Nonstop flight time from TYS to MDH ranges from 1 hours 33 minutes. The route covers a distance of 321 miles (517 km).

Connecting Options and Alternatives

2 one-stop connections are available, with the fastest taking approximately 3 hours via MDW. Nearby alternative airports include Lexington (LEX).